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Profesor Elżbieta Łodyga-Chruścińska

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Zainteresowania naukowe i realizowana tematyka badań

  • Bioinorganic Chemistry.
  • Coordination Chemistry of transition metal ions: Cu(II), Ni(II), Zn(II) i VO(IV).
  • Determining the structure of transition metal ion complexes with biomolecules in  solution and in the solid phase.
  • Thermodynamic and spectroscopic studies of metallodrugs using different analytical techniques: electrochemistry, UV-Vis, EPR, circular dichroism, NMR, ESI MS, fluorymetry.
  • Conducting research in the field of biological chemistry of modified nucleosides, flavonoides and other natural or synthetic compounds and their metal complexes for use in medicine.
  • Research focusing on the coordination chemistry of novel antimicrobial, antifungal and antitumor agents.
Obrazek użytkownika Elzbieta Lodyga Chruscinska
Profesor
Elżbieta
Łodyga-Chruścińska

Stanowisko

profesor

E-mail

elzbieta.lodyga-chruscinska@p.lodz.pl


Działalność dydaktyczna

Lectures:

  • Bioinorganic chemistry on the course of Biotechnology
  • General, Inorganic and Analytical Chemistry on the courses: Biotechnology at International Faculty of Engineering and Food Science & Human Nutrition at Faculty of Biotechnology & Food Sciences
  • Toxicology, on the courses: Environmental Protection and Food Science & Human Nutrition at Faculty of Biotechnology & Food Sciences.
  • Conducting classes with students in the lab:
  • Analytical Chemistry on the course of Biotechnology at International Faculty of Engineering
  • Visiting professor Lecture: „Copper essential or toxic for human life?” Universitá Degli Studi di Sassari, Italy 19.05-26.05 2014
Patenty i zgłoszenia patentowe
  1. Zgłoszenie patentowe: “Pochodna hydrazonowa naryngeniny oraz sposób jej otrzymywania” : 24.11.2015. nr P.414925.
  2. Zgłoszenie patentowe: „Kompleks rutenu(II) oraz sposób jego otrzymania”, z dn. 22.11.2016., nr P. 419556.
Publikacje po 2000 roku
  1. E. Chruścińska, I. Derdowska, H. Kozłowski, B. Lammek, M. Łuczkowski,J. Świątek-Kozłowska, ”Unusual gain in the coordination ability of vasopressin-like peptides towards Cu(II) ions by insertion of the highly hydrophobic side chain” New J. Chem. 27 (2003) 251–256.
  2. E. Garribba, G. Micera, D. Sanna, E. Łodyga-Chruścińska, „Oxovanadium(IV) complexes of quinoline derivatives” Inorg. Chim. Acta, 348, (2003) 97-106
  3. E. Łodyga-Chruścińska, S. Ołdziej, G. Micera, D.Sanna.L.Chruściński, J. Olczak, J. Zabrocki, “Impact of 1,5-disubstituted tetrazole ring on chelating ability of d-selective opioid peptide”, J. Inorg. Biochem., 98 (2004) 447–458
  4. E. Łodyga-Chruścińska, S. Ołodziej, G. Micera, D. Sanna, L. Chruściński, J. Olczak, J. Zabrocki, „Effect of tetrazole moiety on coordinating efficiency of deltorphin”  Acta Chim. Pol., 51 (2004) 93-106.
  5. E. Garriba, E. Lodyga-Chruscinska, G. Micera, A. Panzanelli, D. Sanna, ”Binding of Oxovanadium (IV) to Dipeptydes Containing Histidine and Cisteine Peptide” Eur. J. Inorg. Biochem., (2005), 1369-1382.
  6. E. Garribba, G. Micera, E. Lodyga-Chruscinska, D. Sanna, G. Sanna. "Binding of Oxovanadium(IV) to Tripeptides containing Histidine and Cysteine Residues and its Biological Implication in the Transport of Vanadium and Insulin-Mimetic Compounds" Eur. J. Inorg. Chem. (2005), 4953-4963
  7. E. Łodyga-Chruścińska, D. Sanna., G. Micera, L. Chruściński, J. Olejnik, R. J. Nachman J. Zabrocki, "Chelating ability of proctolin tetrazole analogue" Acta Biochim. Pol.(2006) 53, 65-72.
  8. E. Garribba, G. Micera,.E. Lodyga-Chruscinska D. Sanna, "Oxovanadium(IV) Complexes with Pyrazinecarboxylic Acids: The Coordinating Properties of Ligands with the (N-aromatic, COO-) Donor Set" Eur. J. Inorg. Chem.(2006), 2690-2700.
  9. M. Rangel, E. Garribba, Giovanni Micera, E. Lodyga-Chruscinska  "Spectroscopic and Potentiometric Characterization of Oxovanadium (IV) Complexes formed by 3-Hydroxy-4-Pyridinones. Rationalization of the Influence of Basicity and Electronic Structure of the Ligand on the Properties of Insulin-Mimetic Species in Aqueous Solution" Inorg. Chem. (2006) 45 (8086-8097)
  10. E. Lodyga-Chruscinska, D. Sanna, E. Garribba, G. Micera, "Potentiometric, spectroscopic, electrochemical and DFT characterization of,oxovanadium(IV) complexes formed by citrate and tartrates in aqueous solution at high ligand to metal molar ratios: the effects of the trigonal bipyramidal distortion in bis-chelated species and biological implications", J. Chem. Soc., Dalton Trans., (2008), 4903-4916
  11. E. Łodyga-Chruścińska, S.Ołdziej, D. Sanna, G. Micera L. Chruściński, K. Kaczmarek, R.J. Nachman, J. Zabrocki and A. Sykuła, "Coordination ability of Insect Kinin Analogs",  Polyhedron 28 (2009), pp. 485-492
  12. E.Łodyga-Chruscinska, E.Sochacka, D. Smuga, L. Chruściński, G. Micera, D. Sanna, M. Turek, M. Gąsiorkiewicz, „Histamine modified 20-deoxyriboadenosine – Potential copper binding site in DNAzymes”, J. Inorg. Biochem. 104 (2010) 570-575.
  13. A. Bujacz, M. Turek, W. Majzner, E. Lodyga–Chniscinska*, “X-Ray Structure of a Novel Histidine-Copper(II) Complex”, Russ. J. Coord. Chem. 36 (2010) 430–435.
  14. E. Garribba, E. Łodyga-Chruścińska, G. Micera, "Complex Formation in Aqueous Solution and in the Solid State of the Potent Insulin-Enhancing V(IV)O2+ Compounds Formed by Picolinate and Quinolinate Derivatives" Inorganic Chemistry, 50 (2011) 883–899.
  15. E. Łodyga-Chruścińska, “Tetrazole peptides as copper(II) ion chelators”, Coord. Chem. Rev. 255 (2011) 1824–1833
  16. A. Sykuła-Zając, E. Łodyga-Chruścińska, B. Pałecz, R. Dinnebier, U.J. Griesser V. Niederwanger, “Thermal and X-ray analysis of racemic bupivacaine hydrochloride”, J. Therm. Anal. Calorim. 105 (2011) 1031-1036.
  17. E. Łodyga-Chruścińska, S. Ołdziej, E. Sochacka, K. Korzycka L. Chruściński, G. Micera, D. Sanna, M. Turek, J. Pawlak, “Impact of histidine residue on chelating ability of 2'-deoxyriboadenosine” J. Inorg. Biochem. 105 (2011) 1212-1219.
  18. Chapter in monograph: Impact of Flavonoids on Oxidation Stress. Review  M. Symonowicz and E.L-Chruscinska  printed in, eds J.N. Govil, L. Tiwari, Recent Progress in Medicinal Plants Vol. 35 in 'Phytoconstituents and Biochemical Processes', pp. 1 -10, Studium Press LLC, USA, 2013.
  19. M. Misiak, A. Sykuła-Zając, E. Łodyga-Chruścińska, I. Rumora and M. Straukas “Evaluation of polyphenols and anthocyanins contents in black chockeberry (photinia melanocarpa (michx)) fruits extract”, Acta Poloniae Pharmaceutica - Drug Research, vol. 69 (2012), issue no. 3. pages 381-387.
  20. E. Łodyga Chruścińska, A. Sykuła-Zając, D. Olejnik ” Determination of nickel in Polish brands of margarines”, Food Add. Contam. Vol. 5 (2012) pages 251-254.
  21. E. Lodyga-Chruscinska, A. Szebesczyk, K. Hegetschweiler, G. Micera and E. Garribba“Formation in aqueous solution of non-oxido VIV complex with VN6 coordination. Potentiometric, ESI-MS, spectroscopic and computational characterization.”Dalton Transactions, 2013. 42 13404-13416, DOI: 10.1039/c3dt50969a.
  22. J. Pawlak, E. Łodyga-Chruścińska, J. Chrustowicz, "Fate of platinum metals in the environment" J. Trace Elem. Med Biol., 28 (2014) 247–254.
  23. T. Kolesa-Dobravc, El. Lodyga-Chruscinska, M. Symonowicz, D. Sanna, A. Meden, F. Perdih, E. Garribba, "Synthesis and Characterization of VIVO Complexes of Picolinate and Pyrazine Derivatives. Behavior in the Solid State and Aqueous Solution and Biotransformation in the Presence of Blood Plasma Proteins”, Inorg. Chem. 53 (2014) 7960-7976.
  24. E. Lodyga-Chruscinska, M. Symonowicz, A. Sykula, A. Bujacz, E. Garribba, M. Rowinska-Zyrek., S. Oldziej, E. Klewicka, M. Janicka, K. Krolewska, M. Cieslak, K. Brodowska, L. Chruscinski “Chelating ability and biological activity of hesperetin Schiff base” J. Inorg. Biochem. 143 (2015) 34–47. DOI: 10.1016/j.jinorgbio.2014.11.005
  25. J. Borowska, M. Sierant, E. Sochacka, D. Sanna, E. . Lodyga-Chruscinska*, „ DNA binding and cleavage studies of copper(II) complexes with 2′-deoxyadenosine modified histidine moiety”, J. Biol. Inorg. Chem. 20 (2015) 989–1004. DOI: 10.1007/s00775-015-1282-2.
  26. K. Brodowska, E. Lodyga-Chruscinska, “The Potential Role and Application of Natural Flavonoids and Their Analogues”, Chapter in Monograph: Flavonoids and Antioxidants of the Series "Recent Progress in Medicinal Plants",  Vol.40, 2015, Ch 002, pp. 36- 61 ISBN Of Series   0-9656038-5-7, ISBN OF Volume 1-62699-077-8 Editor of Volume Dr. Manohar Pathak.
  27. A. Sykula, Elzbieta Łodyga-Chruścińska and Aliaksandr  Dzeikala, “Flavonoid Schiff Bases, Their Action And Significance: A Review, Chapter in Monograph: "Recent Progress in Medicinal Plants", (Ch-16), 352-366, Series ISBN    0-9656038-5-7 ISBN Of Volume 1-62699-077-8, Ed. Manohar Pathak, Studium Press LLC, USA, 2015.
  28. K. Brodowska, A. Sykuła, E. Garribba, E. Łodyga-Chruścińska, M. Sójka, “Naringenin Schiff base: antioxidant activity, acid-base profile, and interactions with DNA”, Transition Met. Chem. 41 (2016) 179–189. DOI 10.1007/s11243-015-0010-7
  29. K. Brodowska, I.l Correia, E. Garribba, F.a Marques, E.Klewicka, E. Łodyga-Chruscińska, J.Costa Pessoa, A.Dzeikala, L. Chrusciński, in  J. Inorg. Biochem 165 (2016) 36–48, doi: 10.1016/j.jinorgbio.2016.09.014

  30. E. Łodyga-Chruścińska, K. Brodowska, E. Klewicka, L. Chruściński, „Cooper coordination compounds with novel flavonoid’s Schiff basesRozdział w monografii "Współczesne aspekty badań flawonoidów" pod redakcją M.Kopacz, J.Pusz, J.Kalembkiewicz, wydana przez Oficynę Wydawniczą Politechniki Rzeszowskiej 2016, pp.423-432, ISBN: 978-83-7934-107-8

  31. E. Sochacka, E. Lodyga-Chruscinska, J. Pawlak, M. Cypryk,.P. Bartos, K. Ebenryter-Olbinska, G. Leszczynska and B. Nawrot, “C5-substituents of uridines and 2-thiouridines present at the wobble position of tRNA determine the formation of their keto-enol or zwitterionic forms – a factor important for accuracy of reading of guanosine at the 3’-end of the mRNA codons”, Nucleic Acids Research, (2017), Vol. 45, No. 8 4825–4836. doi: 10.1093/nar/gkw1347

Otrzymane nagrody
  • Awards of the Rector of the Lodz University of Technology
Staże naukowe
  • Dipartimento di Chimica Inorganica, Analitica e Struttura Molecolare, Universita degli Studi di Messina, Italy, 1988/1989, visiting scientist
  • Dipartimento di Chimica, Universita di Sassari, Italy, 1994, visiting scientist
  • Dipartimento di Chimica, Universita di Sassari, Italy, 1997, NATO fellowship
  • Dipartimento di Chimica, Universita di Sassari, Italy, 2001, visiting professor
  • Dipartimento di Chimica, Universita di Sassari, Italy, 2002, visiting professor
  • ASSA International , Stamford, CT, USA, 2003, visiting professor
  • Dipartimento di Chimica, Universita di Sassari, Italy, 2005, visiting professor
  • Dipartimento di Chimica, Universita di Sassari, Italy, 2012, visiting professor
  • Lectures entitled:„Biometals in our life” presented at International Seminars in Life Sciences at Universidad Politecnica De Valencia, 7-11.02. 2012.
  • Plenary lecture entitled: “Impact of histidine residues on coordinating ability of nucleosides”at XXVI. International Conferenceon Coordination and Bioinorganic Chemistry, Smolenice, Slovakia, June 2-7, 2013.
  • Plenary lecture entitled:“Coordinating and biological activities of some flavonoids and their Schiff base analogs” XXV. International Conference on Coordination and Bioinorganic Chemistry Smolenice, Słowacja, May 31-June 5, 2015,
  • Plenary lecture entitled:“Copper coordination compounds with modified small biomolecules”, XIII International Symposium on Inorganic Biochemistry, 1-6 September 2015 Karpacz, Poland,
  • Lectures entitled:“Flavonoid’s Schiff bases –chelating ability and biological activity” presented at Universidade de Lisboa, Portugal Centro de Química Estrutural Complexo Instituto Superior Técnico, 25th May 2015.
  • Dipartimento di Chimica e Farmacia, Universita di Sassari, Italy, 2016, visiting professor
  • Lectures entitled:„Structures, biological activity of modified bioflavonoids and their Copper coordination compounds", Conference organized at Dipartimento di Chimica e Farmacia, Universita di Sassari, Italy,  25.10.2016.
  • Lectures entitled:„Physicochemical and biological properties of a hesperetin hydrazone", Conference "La parola ai giovani" organized at Dipartimento di Chimica e Farmacia, Universita di Sassari, Italy,  28.10.2016.
  • Lecture entitled: “Structure, biological activity of modified bioflavonoids and their copper coordination compounds”, International Workshop on „Bioinorganic Redox Control – Implications for Medicinal Chemistry and Environmental Protection”, 20-21.04.2017. Kraków
  • Plenary lecture: “Physicochemical properties and biological activity of naringenin thiosemicarbazone”, XXVI. Modern Trends in Coordination, Bioinorganic and Applied Inorganic Chemistry, Smolenice, Slovakia June 4–9, 2017.
Przebieg kariery naukowej
  • Msc 1975, Department of Chemistry, Lodz University of Technology
  • PhD. 1984, Department of Food Chemistry, Lodz University of Technology
  • Dr habil. 2003, Department of Chemistry, Lodz University of Technology
  • Professor 2013
Członkostwo w organizacjach pozauczelnianych
  • Polish Chemical Association
Hobby

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Wydział Biotechnologii i Nauk o Żywności

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